METODO PARA INHIBIR UNION DEL RECEPTOR DE MUERTE 6 (DR6) A LA PROTEINA PRECURSORA AMILOIDE (APP) QUE COMPRENDE UNO O MAS ANTAGONISTAS DEL DR6; USO DE DICHOS ANTAGONISTAS; METODO PARA IDENTIFICAR UNA MOLECULA DE INTERES QUE INHIBE LA UNION DEL DR6 A L

摘要

Methods and compositions comprising DR6 antagonists for use in treating neurological disorders, including Alzheimer's disease, are provided. The DR6 antagonists include anti-APP antibodies, anti-DR6 antibodies, DR6 immunoadhesins and DR6 variants (and fusion proteins thereof) which enhance growth, regeneration or survival of mammalian neuronal cells or tissue.