发明名称 |
MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME |
摘要 |
The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site- specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine. |
申请公布号 |
WO2008088104(A1) |
申请公布日期 |
2008.07.24 |
申请号 |
WO2007KR01263 |
申请日期 |
2007.03.14 |
申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY;LEE, SANG YUP;PARK, JIN HWAN;LEE, KWANG HO;KIM, TAE YONG |
发明人 |
LEE, SANG YUP;PARK, JIN HWAN;LEE, KWANG HO;KIM, TAE YONG |
分类号 |
C12N1/16 |
主分类号 |
C12N1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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