MONOCLONAL ANTIBODIES RECOGNIZING THE ENTEROCOCCUS FAECIUM ACM PROTEIN

摘要

Monoclonal antibodies which can bind to the ACM protein of Enterococcus faecium are provided which can be useful in the treatment and protection against infection from enterococcal bacteria such as E. faecium and other bacteria from the genus Enterococcus. The monoclonal antibodies of the invention can be prepared from the ACM protein or from its ligand binding A domain, and these antibodies can also be useful in diagnosing infections caused by E. faecium. Suitable pharmaceutical compositions based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.