OLIGOSACCHARIDES COMPRISING AN AMINOOXY GROUP AND CONJUGATESTHEREOF

摘要

The invention provides methods for the synthesis of oligosaccharides comp rising an aminooxy group. The invention further provides oligosaccharides co mprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mam mal by administration of an oligosaccharide-protein conjugate.