The disclosure includes a composition including a poly(L-glutamic acid) and a NIRF dye. It also includes a method including providing to a plurality of cells an imaging agent including poly(L-glutamic acid), a NIRF dye and then imaging the cells to detect the imaging agent. It further includes a dual functional contrast agent including an MRI agent conjugated with an optical imaging agent. A method of detecting cancer is provided including injecting a dual functional contrast agent into a patient and performing both an MRI and an optical scan. The presence of the agent may indicate cancer. A method of detecting cancer by injecting PG-DTPA-Gd-NIR813 into a patient, then detecting the presence or absence of Gd in a cell or tissue of the patient and detecting the presence or absence of NIR813 in a cell or tissue of the patient is provided. The presence of Gd and NIR813 may indicate cancer.
申请公布号
WO2007134236(A3)
申请公布日期
2008.07.24
申请号
WO2007US68783
申请日期
2007.05.11
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;LI, CHUN;WANG, WEI;MELANCON, MARITES P.;GELOVANI, JURI;MYERS, JEFFREY