CUTANEOUS STABILIZATION BY VACUUM FOR DELIVERY OF MICRO-NEEDLE ARRAY

摘要

A device permits effective engagement of micro-needles with a cutaneous layer thereby to permit for a substance to pass effectively to the cutaneous layer A flexible or non-flexible material supports an array of micro-needles for receiving the surface of the cutaneous layer so that the proximal ends of the micro-needles pierce to effect a passage of a substance with the micro-needles to the cutaneous layer A passageway or bladder acts on the substrate to cause the proximal ends of the micro-needles to pass to the cutaneous layer for passage of a substance associated with the micro-needles to the cutaneous layer The bladder includes apertures located about and spaced from the micro-needles such that suction transmitted though the apertures The micro-needles are mounted with a movable first substrate In one form, the first substrate includes a surface with concavities and the micro-needles are mounted in the concavities, and the apertures are located in the concavities In another form the surface is substantially flat There can be a third layer spaced relative to the second substrate layer at least partly forming a chamber between the second layer and third layer There can be a biasing device for urging the first substrate from the cutaneous layer