COMPOSITIONS AND METHODS FOR REGULATING T CELL ACTIVITY

摘要

The present invention relates to antibodies, antibody fragments, and derivatives thereof that specifically bind to Va7.2-Ja33 T cell receptor polypeptides present on the surface of Mucosal Associated Invariant T (MAIT) cells. The invention also relates to cells producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to purify MAIT cells and/or for diagnostic or therapeutic purposes in subjects.