Methods for treating target joints in inflammatory arthritis using AAV vectors encoding a TNF antagonist

摘要

The present invention provides methods for treating inflammatory arthritis in an individual, comprising administering to the individual an effective amount of AAV (rAAV) vector comprising a polynucleotide encoding a pro-inflammatory cytokine antagonist, wherein the individual is being treated systemically with a polypeptide pro-inflammatory antagonist but still has one or more persistently symptomatic joints.