Single-chain Antibodies Against Human Insulin-Like Growth Factor I Receptor: Expression, Purification, and Effect on Tumor Growth

摘要

A method of inhibiting the growth of hormone dependent tumor cells in a mammal comprises administering to said mammal an insulin-like growth factor receptor (IGF-IR) recombinant antibody, wherein said antibody can be a single-chain recombinant antibody, which can be humanized, capable of blocking agonist interaction with the IGF-IR.