Classes of Compounds that Interact with Integrins

摘要

A method of inhibiting or effecting the activity of an integral receptor which comprises contacting an integrin with a compound of formula I, or a pharmaceutically acceptable salt thereof; General Formula I Wherein the ring may be of any configuration; Z is sulphur, oxygen, CH₂, NH, NR^A or hydrogen, in the case where Z is hydrogen then R¹ is not present, R^A is selected from the set defined for R₁ to R₅, X is oxygen or NR^A providing that at least one X of General Formula I is NR^A, X may also combine independently with one of R₁ to R₅ to form an azide, R 1 to R 5 are independently selected from the group comprising H, -(CO)R₆ or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, wherein R₆ is selected from the group comprising an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, with the proviso that XR₂ or XR₃ or XR₄ or XR₅ is not NH₂, with the further proviso that not more than one of R 2 to R 5 is hydrogen, where the group X is NR^A and R^A is not hydrogen, the groups R^A and the corresponding group R₂ to R₅ may combine to form a cycle.