发明名称 |
Screening method for anti-diabetic compounds |
摘要 |
The present invention relates to a method of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diabetes, the method comprising the steps of (a) contacting a test compound with a cell comprising a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NOs: 1 to 29; (ii) is encoded by a nucleic acid molecule comprising or consisting of the sequence of any one of SEQ ID NOs: 59 to 87; (iii) is a fragment of the protein according to (i) or (ii) and exhibits Eph-Receptor-Tyrosine-Kinase activity; or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits Eph-Receptor-Tyrosine-Kinase activity; and (b) determining whether said test compound, upon contacting in step (a) inhibits the Eph receptor tyrosine kinase activity of said protein wherein said inhibition indicates a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diabetes.
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申请公布号 |
EP1947193(A1) |
申请公布日期 |
2008.07.23 |
申请号 |
EP20070000920 |
申请日期 |
2007.01.17 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
LAMMERT, ECKHARD;KONSTANTINOVA, IRENA |
分类号 |
G01N33/50;C12Q1/48;G01N33/74 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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