发明名称 |
NEW DIAMINEDITHIOL DERIVATIVES AND RADIORHENIUM OR RADIOTECHNETIUM COMPLEX THEREOF; A LIVER CANCER-TREATING COMPOSITION COMPRISING THE RADIORHENIUM COMPLEX AND LIPIODOL; AND A KITFOR PREPARATION OF THE LIVER CANCER-TREATING COMPOSITION |
摘要 |
The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer. In the composition according to the invention, the diaminedithiol derivative is a novel compound in which long chain alkyl groups were introduced to diaminedithiol, capable of forming a radiorhenium or radiotechnetium complex thereof with an ease and leading to stronger van der Waals bonds with lipiodol. As a result, the complex becomes more stable in a medium, lipiodol, whereby the composition of the invention exhibits a high accumulation rate in liver cancer tissue when injected via hepatic artery, thereby capable of achieving an efficient treatment of liver cancer.
|
申请公布号 |
CA2441836(C) |
申请公布日期 |
2008.07.15 |
申请号 |
CA20022441836 |
申请日期 |
2002.03.08 |
申请人 |
SEOUL NATIONAL UNIVERSITY HOSPITAL |
发明人 |
LEE, MYUNG CHUL;LEE, DONG SOO;LEE, YUN-SANG;CHUNG, JUNE-KEY;KIM, YOUNG JU;JEONG, JAE MIN |
分类号 |
A61K9/08;C07C323/41;A61K31/145;A61K31/16;A61K31/395;A61K47/02;A61K47/12;A61K51/00;A61P35/00;C07C381/00;C07D285/00;C07F13/00 |
主分类号 |
A61K9/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|