发明名称 |
Trans-splicing mediated photodynamic therapy |
摘要 |
The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) expressed within a cell and mediate a trans-splicing reaction resulting in the generation of a novel chimeric mRNA molecule (chimeric mRNA) capable of encoding a light producing protein or enzyme. Cell death is further mediated by the presence of a photosensitizer which upon photoactivation produces cytotoxicity.
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申请公布号 |
US7399753(B2) |
申请公布日期 |
2008.07.15 |
申请号 |
US20030658617 |
申请日期 |
2003.09.09 |
申请人 |
VIRXSYS CORPORATION |
发明人 |
MITCHELL LLOYD G.;OTTO EDWARD;MERRIL CARL R. |
分类号 |
C12N5/10;C12N15/09;A61K31/7105;A61K31/711;A61K48/00;C07H21/02;C07H21/04;C12N;C12N1/15;C12N1/19;C12N1/21;C12N5/02;C12N15/00;C12N15/10;C12N15/113;C12N15/62;C12N15/63;C12N15/64;C12N15/66;C12N15/85;C12N15/86;C12N15/861;C12P21/02;C12Q1/02;C12Q1/68 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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