COMPOSITIONS FOR TREATING VITILIGO COMPRISING BEE VENOM AND METHOD FOR SCREENING INHIBITORS AGAINST THE PIGMENTATION INDUCED BY BEE VENOM

摘要

A pharmaceutical composition for treating vitiligo comprising bee venom and a method for screening an inhibitor of pigmentation induced by the bee venom are provided to use the bee venom for treating the vitiligo easily and screen the inhibitor of pigmentation induced by the bee venom in a high-throughput manner. A pharmaceutical composition comprises: a pharmaceutically effective amount of bee venom; and a pharmaceutically acceptable carrier. A method for screening an inhibitor of pigmentation induced by the bee venom comprises the steps of: (a) treating a cell with an inhibitor candidate material; (b) treating the cell with the bee venom; and (c) selecting the candidate material which inhibits phosphorylation of Ca^2+ or a cAMP response element binding protein(CREB) or inhibits expression level of a microphthalmia associated transcription factor(MITF). Further, the cell is a melanin cell.