发明名称 |
USE OF AN NMDA RECEPTOR ANTAGONIST THE TREATMENT OF TINNITUS INDUCED BY COCHLEAR EXCITOTOXICITY |
摘要 |
<p>The invention relates to methods for the prevention and/or treatment of tinnitus induced by cochlear excitotoxicity. In these methods, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and/or formulations for local administration to the inner ear. The tinnitus to be prevented and/or treated may be provoked by acoustic trauma, presbycusis, ischemia, anoxia, treatment with one or more ototoxic medications, sudden deafness, or other cochlear excitotoxic-inducing occurrence. The invention also relates to method for the identification of compounds effective in the treatment and prevention of tinnitus by a novel screening method incorporating an electrophysiological test method.</p> |
申请公布号 |
EP1940370(A2) |
申请公布日期 |
2008.07.09 |
申请号 |
EP20060850445 |
申请日期 |
2006.09.27 |
申请人 |
AURIS MEDICAL AG;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) |
发明人 |
GUITTON, MATTHIEU;PUEL, JEAN-LUC;PUJOL, REMY;RUEL, JEROME;WANG, JING |
分类号 |
A61K31/00;A61K31/135;A61K31/439;A61K31/4535;A61K31/517;A61K31/662;A61K49/00;A61P27/16 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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