POLYMER PARTICLES FOR NIR/MR BIMODAL MOLECULAR IMAGING AND METHOD FOR PREPARING THEREOF

摘要

A method for producing polymer particles for bimodal near infrared(NIR)/magnetic resonance(MR) molecular imaging is provided to obtain biocompatible multi-functional nano- and micro-particles having both magnetic property and fluorescence. A method for producing polymer particles for bimodal NIR/MR molecular imaging comprises the steps of: (a) dispersing an aqueous solution(W1), in which a magnetic nanosubstance and NIR fluorescent substance are dissolved, into an organic polymer solution(O) to obtain a first dispersion(W1/O), wherein at least one of the magnetic nanosubstance and NIR fluorescent substance is hydrophilic; (b) dispersing the first dispersion into an aqueous emulsifier solution(W2) to obtain a second dispersion(W1/O/W2); and (c) stirring and separating the second dispersion to remove the organic solvent of the organic polymer solution of step (a) and the aqueous emulsifier solution of step (b), and to obtain polymer particles.