| 摘要 |
This application relates to 3-phenyl-1-prbpyl(2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate. It further relates to a method of preparing such a compound comprising the step of reacting (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylic acid with 3-phenyl-1-propanol and dicyclohexylcarbodiimide. Finally, the application relates to the intermediate compound (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidinecarboxylic acid which may be used to produce 3-phenyl-1-propyl(2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate. 3-phenyl-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate functions as a rotamase enzyme inhibitor and is therefore useful as a component in pharmaceutical compositions, in particular for promoting neuronal growth and regeneration and for treating neurological disorders. |
