发明名称 |
ANTICANCER DRUG COMPRISING RHODANINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
摘要 |
A rhodanine-based compound or a pharmaceutically acceptable salt thereof is provided to show excellent inhibitory activity on CDC25B phosphatase acting on cell cycle decisively, thereby showing high anticancer activity on cancer cells. A rhodanine-based compound is represented by a formula(1), wherein each Ar1 and Ar2 is independently phenyl or pyridine, which may be substituted by at least two substituents selected from the group consisting of C1-4 alkyl, halogen, C1-7 alkoxy, C3-4 alkenyloxy, C2-4 acyl, cyano or nitro. An anti-cancer agent composition comprises the rhodanine-based compound or a pharmaceutically acceptable salt thereof as an effective ingredient.
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申请公布号 |
KR100844131(B1) |
申请公布日期 |
2008.07.04 |
申请号 |
KR20070000624 |
申请日期 |
2007.01.03 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
JEON, DONG JU;KIM, HYUNG RAE;KIM, KWANG ROK;CHEON, HYAE GYEONG;SEO, MIN JUNG |
分类号 |
C07D409/06;C07D409/14 |
主分类号 |
C07D409/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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