COMPUESTOS ANALOGOS DE ADENOSINA; COMPUESTOS INTERMEDIARIOS; COMPOSICION FARMACEUTICA; Y USO EN EL TRATAMIENTO DE ENFERMDADES TALES COMO FIBROSIS QUISTICA, OTITIS MEDIA, ASMA, ULCERA PEPTICA, ENTRE OTRAS.

摘要

Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.