NEW BISPHENYL DERIVATIVES, A METHOD FOR PREPARING THEREOF, AND USE AS ADP-RIBOSYL CYCLASE INHIBITORS

摘要

A bisphenyl derivative is provided to obtain an ADP-ribosyl cyclase inhibitor having selectivity to each tissue cell and useful for preventing and/or treating cardiac, renal or cerebral diseases. A bisphenyl derivative is represented by the following formula 1. In formula 1, X and Y are linked to each other via a single bond or double bond, and each represents carbon, nitrogen, sulfur or oxygen; and each of R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 is selected from the group consisting of hydroxyl(OH), hydrogen(H), amine(-NH2), amide(-NH), nitro(-NO2), nitroso(-NO), carboxyl(-COOH), aldehyde(-CHO), carbonyl(-C=O), sulfhydryl(-SH) and sulfoxyl(-SO3H).