| 摘要 |
The present invention is a device for delivering insulin to a subject with impaired hepatic glucose processing. The device delivers a series of pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The amount of insulin in each pulse, the interval between pulses and the amount of time to deliver each pulse to the subject are selected so that the hepatic processing of glucose is restored in the subject. Initially after ingestion of the carbohydrate containing meal, the subject's circulating blood glucose level rises. In subjects whose hepatic glucose processing has been restored there is a subsequent fall in circulating blood glucose levels of 50 mg/dl or more directly as a result of hepatic glucose processing being restored to the liver. |
