| 摘要 |
PROBLEM TO BE SOLVED: To provide a new semi-synthetic macrolide compound which has an immunomodulation activity and minimizes side effects. SOLUTION: This new semi-synthetic macrolide compound is obtained by converting a specific site of rapamycin into a specific substituent. The semi-synthetic macrolide has an immunomodulation action, and is effective for autoimmune diseases such as rejection, chronic articular rheumatism, systemic lupus erythematosus, chronic lymphocytic thyroiditis (Hashimoto disease), multiple sclerosis, myasthenia gravis, type I diabetes, uveitis, allergic encephalomyelitis, and glomerulonephritis. COPYRIGHT: (C)2008,JPO&INPIT
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