The use of a borate/polyol and zinc system to enhance the antimicrobial activity of multi-dose pharmaceutical compositions is described. The compositions do not require a conventional anti-microbial preservative and therefore are referred to as being 'self-preserved'. The compositions possess sufficient antimicrobial activity to satisfy the preservative efficacy requirements of the USP for aqueous ophthalmic compositions.
申请公布号
WO2008042619(A3)
申请公布日期
2008.07.03
申请号
WO2007US79094
申请日期
2007.09.20
申请人
ALCON RESEARCH, LTD.;CHOWHAN, MASOOD A.;KEITH, DAVID, J.