| 摘要 |
The present invention relates to the synergistic effects of a combined administration of a Rho antagonist, e.g. a C3 fusion protein, with a growth factor, e.g. CNTF, and cAMP or analogues or modulators thereof, which have synergistic effects on promoting neuronal, e.g. adult RGC survival and axonal regeneration. The present invention relates therefore to compositions, and to methods for treating comprising administering the compositions of the invention to a subject in need thereof, for promoting neuronal, e.g. adult RGC survival and axonal regeneration in a subject. Exemplary compositions of the invention comprise Rho antagonists, e.g. C3 proteins or C3-like proteins, growth factors such as CNTF, and CAMP, or analogues or modulators thereof. It is also provided that the effects of administering SEQ ID NO: 4, CNTF and cAMP or CPT-CAMP are synergistic, increasing both the number of surviving RGCs and the proportion of viable RGCs that regenerate an axon. |
