DRUG DELIVERY WITH STIMULUS RESPONSIVE BIOPOLYMERS
摘要
The present invention provides conjugate compounds comprising (a) an active compound; (b) optionally, but in some embodiments preferably, an affinity binding agent; and (c) a block copolymer, the block copolymer comprising: (i) a first elastin-like polypeptide having a first Tt and (U) a second elastin-like polypeptide having a second Tt greater than the first Tt. Method for the targeted delivering of an active compound in vivo to a selected region within a subject with such agents are also described.
申请公布号
WO2008036147(A3)
申请公布日期
2008.07.03
申请号
WO2007US16152
申请日期
2007.07.17
申请人
DUKE UNIVERSITY;CHILKOTI, ASHUTOSH;DREHER, MATTHEW, ROBERT;MEYER, DANIEL, EUGENE