MODIFIED PEPTIDE YY AND CONJUGATE THEREOF

摘要

PROBLEM TO BE SOLVED: To modify a therapeutic peptide to be protected from peptidase activity and to give long lasting of activities in vivo while the peptide keeps low toxicity and retains therapeutic merits of the modified peptide. SOLUTION: A modified therapeutic peptide is provided, which therapeutic peptide can form a peptidase-stabilized therapeutic peptide conjugate, and which peptide contains carboxy-terminal amino acids, amino-terminal amino acid, and therapeutically active regions and lowly therapeutically active regions, identified by structural activity-concerning analysis. The peptide is characterized by containing a specific derivative having a reactive group to be bonded with amino acid positioned in the lowly therapeutically active region of amino acid. COPYRIGHT: (C)2008,JPO&INPIT