| 摘要 |
The present invention describes a detection device based on the surface plasmon resonance effect, comprising a radiation emitter (20) and a radiation detector (30), a fluidic substrate (40), a liquid crystal layer and respective control mechanism (80), wherein: (a) the fluidic substrate (40) includes channels (43) and at least one detection surface (42) containing a thin electrically conductive layer behaving like a diffraction grating; (b) the liquid crystal layer (80) is placed in between the radiation emitter (20) and the radiation detector (30) and is capable of presenting at least two types of orientation of its molecules in order to induce different levels of modification of the properties of the radiation outgoing (102) or radiation incident (101) onto the detection surface (42); (c) the control mechanism is present for controlling the average orientation of the molecules (83) of the liquid crystal layer (80), in order to adjust the modification of the radiation properties, to optimize detection of the surface plasmon resonance signal; (d) by exploiting the surface plasmon resonance effect, the arrangement enables to conduct measurements of chemical and/or biological events occurring in the vicinity of the detection surface (42) of the detection zone (41). Surface plasmon resonance detection is achieved through the adjustment of the properties of the radiation outgoing (102) or radiation incident (101) onto the detection surface (42) though the control of the liquid crystal layer (80). |
