发明名称 |
METHODS AND COMPOSITIONS FOR MONITORING T CELL RECEPTOR DIVERSITY |
摘要 |
The present invention provides an array for use in a method of monitoring T cell diversity. The array comprises a substrate having a plurality of capture probes that can specifically bind to a nucleic acid molecule corresponding to a T cell receptor (TCR) gene family selected from the group consisting of the TCR gene families listed in Table 1. In one format, the system has one or more oligonucleotide capture probes wherein each probe is selected from the group consisting of SEQ ID NO: 1-41. Further provided are methods for monitoring T cell diversity in a subject following, for example, allogeneic hematopoietic stem cell transplantation, or other treatment or therapy that contributes to an alteration in T cell population and/or diversity. Compositions of the invention include arrays, computer readable media, and kits for use in the methods of the invention. |
申请公布号 |
WO2008039694(A3) |
申请公布日期 |
2008.07.03 |
申请号 |
WO2007US79108 |
申请日期 |
2007.09.21 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL;CHEN, XIAOHUA;NEALE, GEOFFREY, A.M.;HANDGRETINGER, RUPERT |
发明人 |
CHEN, XIAOHUA;NEALE, GEOFFREY, A.M.;HANDGRETINGER, RUPERT |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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