发明名称 |
BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS |
摘要 |
<p>The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z<SUP>1</SUP>, Z<SUP>2</SUP>, Z<SUP>3</SUP>, Z<SUP>4</SUP>, R<SUP>8</SUP>, and R<SUP>9</SUP> are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.</p> |
申请公布号 |
WO2008079759(A1) |
申请公布日期 |
2008.07.03 |
申请号 |
WO2007US87704 |
申请日期 |
2007.12.17 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;WURTZ, NICHOLAS RONALD;PRIESTLEY, ELDON SCOTT;CHENEY, DANIEL L.;ZHANG, XIAOJUN;PARKHURST, BRANDON;LADZIATA, VLADIMIR |
发明人 |
WURTZ, NICHOLAS RONALD;PRIESTLEY, ELDON SCOTT;CHENEY, DANIEL L.;ZHANG, XIAOJUN;PARKHURST, BRANDON;LADZIATA, VLADIMIR |
分类号 |
C07D401/12;A61K31/4725;A61P7/02 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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