PROTEASE INHIBITORS

摘要

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2-, 3- pyridyl-CH2-, 4-pyridyl-CH2-, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thio phenesulfonyl groups, R2a-CO)-, R2a being selected from the group consisting of piperonyl, 2-pyranzinyl (unsubstituted or substituted with H, or an alky l of 1 to 4 carbon atoms) or a picolylamine group as described herein, where in R3 may be, for example, a phenyl group or diphenylmethyl group as describ ed herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR 7.