METHOD FOR MODULATING INFLAMMATORY RESPONSES

摘要

The present invention is a method for inhibiting T^reg cell functional activities by blocking T^reg cell-mediated mast cell activation. It has been found that IL-9 produced by T^reg cells activates mast cells, which in turn mediate an amplification loop critical for graft tolerance and immune responses to tumors. Thus, a method for enhancing an immune response to a vaccine, such as a cancer vaccine, is also provided as is a method for increasing cell and humoral immunity in a subject.