发明名称 |
QUINOLINE COMPOUNDS, INTERMEDIATES, PREPARTION METHODS AND USES THEREOF |
摘要 |
A kind of quinoline compounds as formula A, pharmaceutical accepted solvates, optical isomers or polymorphisms thereof. The intermediates of formula D. in which, R<SUB>1</SUB>, R<SUB>2</SUB> and R<SUB>3</SUB> is independently H, halo or the subustitents of formula H, in which, R is H, halo, C<SUB>1</SUB>~C<SUB>4</SUB>alkyl, C<SUB>1</SUB>~C<SUB>4</SUB>alkoxyl. The preparation methods and the the uses for the manufacture of a medicament of inhibiting the HMG CoA reductase and treating the diseases relating to the high blood fat. Compared with the fluvastatin, rosuvatatin, pitavastatin disclosed in the prior arts, present quinoline compounds have better activity of inhibiting HMG CoA reductase. Present quinoline compounds can be used for treating the diseases relating to the high blood fat. |
申请公布号 |
WO2008077305(A1) |
申请公布日期 |
2008.07.03 |
申请号 |
WO2007CN03469 |
申请日期 |
2007.12.06 |
申请人 |
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY;CAI, ZHENGYAN;ZHOU, WEICHENG;HAO, QUN |
发明人 |
CAI, ZHENGYAN;ZHOU, WEICHENG;HAO, QUN |
分类号 |
C07D215/36;A61K31/47;A61P3/06;C07D215/14 |
主分类号 |
C07D215/36 |
代理机构 |
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