| 摘要 |
The present invention relates to a compound according to formula: (I); wh erein X1, X2, X3, X4 and X5 independently of each other represent -CH- or N; or X3, X4 and X5 independently of each other represent -CH- or N, and Xi an d X2 independently of each other represent C and form part of an additional 6- membered aromatic ring; R1 represents hydrogen, alkyl, alke nyl, alkynyl, haloalkyl, hydroxyalkyl, or alkylcarbonyl, all of which are optionally subs tituted; R2 and R3 independently represent hydrogen, -CH2-C(O)NR-R', alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, haloalkyl, hydroxyalkyl, heteroc ycloalkenyl, alkylaryl, alkylalkoxycarbonyl, alkylcarbonyloxy, or alkoxyalky l, all of which are optionally substituted; R11 represents hydrogen, halogen , cyano, amino, alkoxy or alkylamino, X1-X5 represent -CH- or N, including N -oxides, enantiomers and diastereomers; and pharmaceutically acceptable salt s, hyd rates, or solvates thereof. The invention relates further to processe s for the preparation of said compounds, to said compounds for use in therap y, to pharmaceutical compositions comprising said compounds, to methods of t reating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
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