发明名称 |
TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP) LINKED TO GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) -ANCHORS FOR TREATMENT OF SKIN LESIONS |
摘要 |
The present invention relates to the use of fusion constructs of glycosylphosphatidylinositol (GPI)-anchored tissue inhibitors of metalloproteinases (TIMPs) for the treatment of cancer. In one embodiment, the TIMP is linked to mucin followed by GPI for surface membrane presentation. The invention further relates to the use of TIMP-GPI or TIMP-mucin-GPI for inhibiting cancer cell proliferation both in vitro and in vivo. The GPI-anchored TIMP proteins are incorporated in the surface membrane of tumour cells and render tumour cells sensitive to FAS-induced apoptosis. This approach makes the GPI-anchored TIMPs useful as anti-cancer agents for the treatment of cancer, and, in particular, residual cancer after incomplete surgical resection of primary tumours in an individual. |
申请公布号 |
EP1937725(A1) |
申请公布日期 |
2008.07.02 |
申请号 |
EP20060805780 |
申请日期 |
2006.09.20 |
申请人 |
HUSS, RALF;NELSON, PETER JON |
发明人 |
HUSS, RALF;NELSON, PETER JON |
分类号 |
C07K19/00;A61K38/57;C07K14/81;C12N15/62 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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