发明名称 |
Synthetic platelets |
摘要 |
<p>A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.
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申请公布号 |
EP1935409(A3) |
申请公布日期 |
2008.07.02 |
申请号 |
EP20070017593 |
申请日期 |
2007.09.07 |
申请人 |
CANADIAN BLOOD SERVICES |
发明人 |
GYONGYOSSY-ISSA, MARIA I.C.;KIZHAKKEDATHU, JAYACHANDRAN N.;CONSTANTINESCU, IREN;CAMPELL, WILLIAM;DEL CARPIO MUNOZ, CARLOS A. |
分类号 |
A61K9/127;A61K9/16;A61K9/51;C07K14/705 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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