发明名称 Use of specific cyclolignans
摘要 The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9' have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin.
申请公布号 EP1938819(A2) 申请公布日期 2008.07.02
申请号 EP20080150437 申请日期 2002.06.19
申请人 AXELAR AB 发明人 LARSSON, OLLE;AXELSON, MAGNUS
分类号 A61K31/36;A61K31/34;A61K31/365;A61P5/06;A61P9/10;A61P17/06;A61P35/00;A61P35/02;A61P43/00;C07D317/54;C07D317/70;C07D493/04 主分类号 A61K31/36
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