发明名称 |
PROCESSES FOR THE PURIFICATION OF (3R,4S)-4-(4-HYDROXY-PROTECTED-PHENYL)-1-(4-FLUOROPHENYL)-3-(4-FLUOROPHENYL)-3-OXOPROPYL¨AZETIDIN-2-ONE |
摘要 |
<p>Provided are processes for purifying (3R,4S)-4-(4-hydroxyprotected-phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one having the following formula II wherein X and Y are hydrogen or a substituted or unsubstituted C<SUB>1-8 </SUB>alkyl; n is an integer between 0 and 3; and P is a hydroxyl protecting group. The Compound of formula II may be converted to an azetidinone compound, which is useful, for example, in reducing cholesterol in mammals.</p> |
申请公布号 |
EP1937636(A1) |
申请公布日期 |
2008.07.02 |
申请号 |
EP20070755415 |
申请日期 |
2007.04.10 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
KANSAL, VINOD, KUMAR;AHMAD, SUHAIL;SETHUMADHAVAN, SANKARAN;MARIAPPAN, SHANMUGAVEL |
分类号 |
C07D205/08;A61K31/397;A61P3/06;C07D405/06 |
主分类号 |
C07D205/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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