发明名称 |
PHARMACEUTICAL FOR PROTECTION OF MOTOR NERVE IN PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS |
摘要 |
The present invention relates to an agent for protecting a motor nerve of a patient with amyotrophic lateral sclerosis, which comprises a combination of (a) (2R)-2-propyloctanoic acid or a salt thereof and (b) a therapeutic agent for amyotrophic lateral sclerosis such as riluzole. An agent comprising a combination of (a) (2R)-2-propyloctanoic acid which is orally administered once a day in an amount per dose of about 1200 mg and (b) riluzole which is orally administered twice a day in an amount per dose of about 50 mg is useful for protecting a motor nerve in a patient(s) with amyotrophic lateral sclerosis. The agent can also suppress the respiratory disability associated with the progression of the disease condition and improve the survival rate of the patient(s).
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申请公布号 |
EP1938814(A1) |
申请公布日期 |
2008.07.02 |
申请号 |
EP20060811858 |
申请日期 |
2006.10.17 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
NISHII, MIKIO;FUNAKOSHI, YOSUKE;IMAGAWA, MASAYUKI;ABE, SHINICHIRO;KUWAYAMA, TOMOHIRO |
分类号 |
A61P11/00;A61K31/20;A61K31/428;A61K45/00;A61P21/00;A61P25/02 |
主分类号 |
A61P11/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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