发明名称 |
Antisense oligonucleotides targeted to human CDC45 |
摘要 |
Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are disclosed. One aspect provides an antisense oligonucleotides that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication-initiation gene. By administering a therapeutically effective amount of antisense oligonucleotides or by contacting the hyperproliferating cells with an effective amount of antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also disclosed.
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申请公布号 |
US7393950(B2) |
申请公布日期 |
2008.07.01 |
申请号 |
US20020232923 |
申请日期 |
2002.08.29 |
申请人 |
HONG KONG UNIVERSITY OF SCIENCE & TECHNOLOGY |
发明人 |
LIANG CHUN;FENG DAO-RONG;YU ZHI-LING |
分类号 |
C07H21/04;A61K31/70;A61K38/00;C12N15/113 |
主分类号 |
C07H21/04 |
代理机构 |
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地址 |
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