发明名称 Tetrahydropyran compounds as tachykinin antagonists
摘要 The present invention relates to compounds of formula (Ia) wherein A, B, n, m, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>7</SUP>, R<SUP>8</SUP>, R<SUP>9</SUP>, R<SUP>10 </SUP>and R<SUP>11 </SUP>are defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
申请公布号 US7393858(B2) 申请公布日期 2008.07.01
申请号 US20050548678 申请日期 2005.09.08
申请人 MERCK SHARP & DOHME LTD. 发明人 DIRAT OLIVIER;ELLIOTT JASON MATTHEW;HUSCROFT IAN THOMAS;JELLEY RICHARD ALEXANDER;KULAGOWSKI JANUSZ JOZEF;RAUBO PIOTR ANTONI;SHAW DUNCAN EDWARD;STERNFELD FRANCINE;SWAIN CHRISTOPHER JOHN
分类号 A61K31/438;A61P25/00;A61P29/00;C07D405/04;C07D405/06;C07D407/12;C07D417/04;C07D491/10;C07D498/04 主分类号 A61K31/438
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