HEPATITIS C VIRUS POLYMERASE INHIBITORS WITH HETEROBICYCLIC STRUCTURE

摘要

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I:
wherein: A is O, S, N R 1 , or C R 1 , wherein R 1 is defined herein;
----- represents either a single or a double bond; R 2 is selected from: H, halogen, R 21 , O R 21 , S R 21 , COO R 21 , SO 2 N( R 22 ) 2 , N( R 22 ) 2 , , CON( R 22 )2 , N R 22 C(O) R 22 or N R 22 C(O)N R 22 wherein R 21 and each R 22 is defined herein; B is N R 3 or C R 3 , with the proviso that one of A or B is either C R 1 or C R 3 ,
wherein R 3 is defined herein; K is N or C R 4 , wherein R 4 is defined herein; L is N or C R 5 , wherein R 5 has the same definition as R 4 defined above; M is N or C R 7 , wherein R 7 has the same definition as R 4 defined above; Y 1 is O or S; Z is N( R 6a ) R 6 or O R 6 , wherein R 6a is H or alkyl or N R 61 R 62 wherein R 61 and R 62 are defined herein;
a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.