PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF CANCERS CONTAINING INDOLE DERIVATIVES AS AN ACTIVE INGREDIENT

摘要

A pharmaceutical composition containing indole derivatives is provided to inhibit activity of HIF-1(hypoxia inducible factor-1) as a transcription factor induced hypoxia, so that the composition is useful for the prevention and treatment of cancers including liver cancer, stomach cancer and breast cancer. A pharmaceutical composition for the prevention and treatment of cancers contains indole derivatives represented by the formula(1) or pharmaceutically acceptable salts thereof, wherein R is COORa, CONRbRc or C1-C4 alkyl group; Ra is H or C1-C4 alkyl; and Rb and Rc are each independently C1-C5 alkyl group substituted by C3-C5 heteroaryl group containing N, O or S or C3-C5 heterocycle group containing N, O or S, H or C1-C5 alkyl group. Further, the pharmaceutical composition is used as a pharmaceutical composition for treating diabetic retinopathy or rheumatoid arthritis.