发明名称 |
COMPUESTOS DERIVADOS DE 5-HIDROXIMETIL OXAZOLIDIN-2-ONA; COMPOSICION FARMACEUTICA QUE CONTIENE A DICHOS COMPUESTOS; Y SU USO PARA TRATAR Y PREVENIR INFECCIONES BACTERIANAS. |
摘要 |
The invention relates to novel chimeric antibiotics of formula (I) wherein R<SUP>1</SUP> represents OH, OPO<SUB>3</SUB>H<SUB>2</SUB> or OCOR<SUP>5</SUP>; R<SUP>2</SUP> represents H, OH or OPO<SUB>3</SUB>H<SUB>2</SUB>; A represents N or CR<SUP>6</SUP>; R<SUP>3 </SUP> represents H or fluorine; R<SUP>4</SUP> is H, (C<SUB>1</SUB>-C<SUB>3</SUB>) alkyl, or cycloalkyl; R<SUP>5</SUP> is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; R<SUP>6</SUP> represents H, alkoxy or halogen; and n is O or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula (I). These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections). |
申请公布号 |
CL2007003232(A1) |
申请公布日期 |
2008.06.27 |
申请号 |
CL20070003232 |
申请日期 |
2007.11.09 |
申请人 |
ACTELION PHARMACEUTICALS LTD. |
发明人 |
CHRISTIAN HUBSCHEWERLEN, PHILIPPE PANCHAUD Y JEAN-LUC SPECKLIN. |
分类号 |
A61K31/4709;A61P31/04;C07D405/14 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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