Catalytic asymmetric hydrogenation of a prochiral beta-substituted enamine, comprises placing a charge of the enamine in a reactor and subjecting the reaction medium in the reactor to a pressure of hydrogen and to a temperature

摘要

Process for catalytic asymmetric hydrogenation of a prochiral beta -substituted enamine, of which the nitrogen is trisubstituted, to obtain a chiral amine as the reaction product constituted of more than 50 wt.% of one of its two enantiomers, comprises placing a charge of the enamine in a reactor for hydrogenating its precursors (aldehyde+amine) in solution in a liquid medium of agitated dissolution, and subjecting the reaction medium in the reactor to a relative pressure of hydrogen and to a temperature sufficient for the hydrogenation in industrially exploitable manner. Process for catalytic asymmetric hydrogenation of a prochiral beta -substituted enamine, of which the nitrogen is trisubstituted, to obtain a chiral amine as the reaction product constituted of more than 50 wt.% of one of its two enantiomers, comprises placing a charge of the enamine in a reactor for hydrogenating its precursors (aldehyde+amine) in solution in a liquid medium of agitated dissolution in which a catalyst is dissolved for hydrogenation reaction, such catalyst is constituted of at least a metal complex constituted of a group VIII metal coordinated by at least a chiral ligand, and subjecting the reaction medium in the reactor to a relative pressure of hydrogen and to a temperature sufficient for the hydrogenation in industrially exploitable manner using an ionic liquid as liquid dissolution medium, where the metal (or metals) of catalyst is in the cationic form and is associated with at least a non-coordinating anion. Independent claims are included for: (1) a device for implementing the process, comprising a reactor (1) able to withstand at internal relative pressure of 20 MPa, where the reactor is associated with an adjustable heating system (2) and a means of agitation (3) and fed in hydrogen, enamine, third solvent, ionic liquid and a catalyst, outlet (8) of the reactor traverse a medium for reducing the pressure and optionally the temperature of the effluent and conducting the effluent to a phase separator (10) that separates the effluent into an organic phase (A) and an ionic phase (B), where the ionic phase is evacuated from separator and returned through a pump (15) in the reactor, and the organic phase is recovered to provide the desired amine; and (2) a chiral amine obtained by the hydrogenation process.