COMPUESTOS DERIVADOS DE 5-OXO-5,8-DIHIDRO-PIRIDO-PIRIMIDINAS, INHIBIDORES C-FMS QUINASA; COMPOSICION FARMACEUTICA; Y USO PARA EL TRATAMIENTO DE ENFERMEDADES TALES COMO EPOC, ASMA, INFECCION POR VIH, PSORIASIS, DIABETES, OBESIDAD Y CANCER DE TUMORES S

摘要

The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form thereof, wherein A, Y, Z, R¹⁰¹ and R²⁰⁰ are described in the specification.