| 发明名称 |
USE OF LECITHIN:RETINOL ACYL TRANSFERASE GENE PROMOTER METHYLATION IN EVALUATING THE CANCER STATE OF A SUBJECT |
| 摘要 |
<p>The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter me thylation status. Methods of analyzing and quantifying LRAT gene promoter me thylation level are also disclosed. The present invention also relates to me thods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detectio n, diagnosis, prognosis, and treatment are also disclosed.</p> |
| 申请公布号 |
CA2675245(A1) |
申请公布日期 |
2008.06.26 |
| 申请号 |
CA20072675245 |
申请日期 |
2007.12.19 |
| 申请人 |
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;SLOAN KETTERING CANCER CENTER;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
BARANY, FRANCIS;PATY, PHILIP;NOTTERMAN, DANIEL;CHENG, YU-WEI |
| 分类号 |
C12Q1/68;C07H21/00;C12N15/11;C12P19/34;C40B30/04 |
主分类号 |
C12Q1/68 |
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