MONOPHOSPHATES AS MUTUAL PRODRUGS OF ANTI-INFLAMMATORY SIGNAL TRANSDUCTION MODULATORS (AISTM'S) AND ~-AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION

摘要

A mutual prodrug of an AISTM and a .beta.-agonist in formulation for deli very by aerosolization to inhibit pulmonary inflammation and bronchoconstric tion is described. The mutual prodrug is preferably formulated in a small vo lume solution (10-500 .mu.L) dissolved in a quarter normal saline having pH between about 5.0 and 7.0 for the treatment of respiratory tract inflammatio n and bronchoconstriction by an aerosol having mass median average diameter predominantly between about 1 to 5 .mu., produced by nebulization or by dry powder inhaler.