| 摘要 |
The present invention provides novel methods and kits for diagnosing the presence of cancer within a patient, and for determining whether a subject w ho has cancer is susceptible to different types of treatment regimens. The c ancers to be tested include, but are not limited to, prostate, breast, lung, gastric, ovarian, bladder, lymphoma, mesothelioma, medullablastoma, glioma, and AML. Identification of therapy-resistant patients early in their treatm ent regimen can lead to a change in therapy in order to achieve a more succe ssful outcome. One embodiment of the present invention is directed to a meth od for diagnosing cancer or predicting cancer- therapy outcome by detecting the expression levels of multiple markers in the same cell at the same time, and scoring their expression as being above a certain threshold, wherein th e markers are from a particular pathway related to cancer, with the score be ing indicative or a cancer diagnosis or a prognosis for cancer-therapy failu re. This method can be used to diagnose cancer or predict cancer-therapy out comes for a variety of cancers. The markers can come from any pathway involv ed in the regulation of cancer, including specifically the PcG pathway and t he "sternness" pathway. The markers can be mRNA, microRNA, DNA, or protein.< /SDOAB>
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