OPTICAL RESOLUTION METHOD

摘要

PROBLEM TO BE SOLVED: To provide an optical resolution method by which an amino compound can effectively optically be resolved through an amide compound. SOLUTION: This optical resolution method for optically resolving an amino compound is characterized by comprising the following processes: (a) a process for thermally reacting an optically active pantolactone represented by general formula (I) (R1is H, a 1 to 4C alkyl or an aralkyl; * is the asymmetric carbon of either of S-arrangement and R-arrangement) with an amino compound of an enantiomer mixture to obtain a pantamide compound which is a mixture of two kinds of diastereomers; (b) a process for separating a diastereomer from the mixture of two kinds of the diastereomers; and (c) a process for hydrolyzing the separated one diastereomer of a pantamide compound to obtain the optically active amino compound. COPYRIGHT: (C)2008,JPO&INPIT