| 摘要 |
A method for local delivery of a drug is provided. The method comprises acts of: (a) implanting a medical device including a drug-containing coating in a patient for the delivery of the drug, wherein the coating comprises a drug and a polymer; and (b) applying an electric current for an interval of time to the topcoat to cause the polymer to transform from a crystalline structure to an amorphous structure so as to increase the rate of release of the drug during the time interval, wherein after the electric current is terminated, the crystallinity of the polymer returns back to essentially the same degree of crystallinity or a more crystalline structure than that of when the polymer was exposed to the current.
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